Journal of Liver Cancer

Heon Young Lee

2 Articles

Spontaneous Regression of Recurred Hepatocellular Carcinoma with Multiple Lung Metastases: Beom Yong Yoon, Heon Young Lee, Se Woong Hwang, Se Young Park, Hye Jin Kim, Hye Won Jang,, Byung Seok Lee; J Liver Cancer. 2015;15(1):46-51. Published online March 31, 2015; DOI: https://doi.org/10.17998/jlc.15.1.46

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Abstract PDF: Hepatocellular carcinoma (HCC) is the most common form of liver malignancy. Spontaneous regression of HCC is extremely rare phenomenon and mechanism of regression remains obscure. 75-year-old woman previously diagnosed with hepatitis C virus-related liver cirrhosis was found to have single mass in liver with elevation of α-fetoprotein level to 10,320 ng/mL. Transarterial chemoembolization (TACE) was performed. 27 months after TACE recurred HCC with multiple lung nodules were confirmed. The patient refused any therapeutic modality. The patient underwent follow-up without any anti-cancer treatment. 8 months after recurrence follow up computed tomography scan revealed spontaneous regression of HCC and completely disappeared lung nodules. The patient is currently doing well and without any evidence of recurrence. The causes of spontaneous regression of HCC are not well understood. Proposed mechanisms are ischemic injury, biological factors, herbal medicine, immunological variations. Further studies are necessary to improve our understanding of this rare phenomenon.

A Case of Extrahepatic Biliary Obstruction by Hepatocellular Carcinoma: Heon Young Lee, Nam Jae Kim, Byung Seok Lee, Jae Kyu Sung, In Sang Song, Dae Yeong Kang; Journal of the Korean Liver Cancer Study Group. 2001;1(1):80-84. Published online June 30, 2001

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Abstract PDF: A 47 year-old female patient admitted due to right upper quadrant and epigastric pain for 3-4 days. She was in shock state on admission and had tenterness on right upper quadrant with jaundice. Blood WBC was 16,900/mm3. Hb was 12.8 g/dL and Platelet count was 94,000/mm3. Serum AST and ALT were 135 and 108 IU/L respectively, and total bilirubin was 7.1 mg/dL. Abdominal CT showed multiple intrahepatic stones with low density lesion at S 6 & 7 and distal intrahepatic duct dilatation. Also distal common bile duct stones with duct dilatation were noted. PTC demonstrated large two filling defect at the common hepatic duct and one another filling defect at the distal common bile duct. PTC also revealed nonvisualization of right posteroinferior intrahepatic duct. Under the diagnosis of multiple right intrahepatic and common bile duct stones with cholangitis, liver abscess, septic shock, we performed PTBD and administration of antibiotics. Because of continuing febrile condition, we studied of abdominal CT that showed more increase size of low density lesion at right lobe of liver and metastatic lymphadenopathy at portahepatis, portocaval and diaphragmatic areas. Aspiration of abscess was tried, but could not gain put, hence biopsy was performed. Pathologic diagnosis was hepatocellular carcinoma. Operation of remval of the bile duct tumor and stones, cholecystectomy with T-tube drainage, right hepatic artery ligation was performed. After operation, she was fair and T-tube was kept.